See returnoftheredi's diary for more info.
It's been blamed on a bug in the mod_virgule code that doesn't handle disk full errors, but I'm skeptical whether the disk fills up often enough to account for the frequency of the problems.
While I'm here, might as well mention I made a new release of PStreams at the weekend, which includes streambuf::in_avail() support and a close-on-exec trick to detect when the child process fails to execute, courtesy of slamb.
Oh, and it seems that by upgrading to a newer /etc/modprobe.conf.dist I've cocked up my sendmail config so that SMTP AUTH no longer works. Damn.